We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The article devoted to one of the lesser-known monasteries of our country, the Saint-Dormition Cosmas male monastery located in the Alexandrovsky district of Vladimir region. On the basis of archival and published materials, the author considers the founding date of the monastery that varies in different lists of life of St. Cosmas of Yakhromsk. In addition, the author concludes that the miraculous finding of the Yakhromsk icon of the Blessed Virgin by St. Cosmas could happened twenty years earlier than (...) it is considered. That can also change the date of the founding of the monastery. In the article, the author studies the question of the origin of the St. Cosmas of Yakhromsk and concludes that St. Cosmas could be a relative of the Gur’evs-Sekerins, the famous Russian boyar family, which is among the ancestors of A. S. Pushkin. The author of the article also tells about the shrines of the Cosmas monastery and their fate nowadays. It is suggested that the Yakhromsk icon of the Blessed Virgin Mary that is currently kept in the Annunciation Cathedral of the Moscow Kremlin could be the icon that was revealed to the St. Cosmas, with which he went to the Kiev-Pechersk monastery, where he was tonsured. If this assumption is true, the Image of the Blessed Virgin Mary of Yakhromsk described by the famous Russian art historian N.P. Kondakov in 1912 is a more recent copy of this icon. The author also gives a brief outline of the history of the monastery in pre-revolutionary and Soviet times and tells about Vladimir restorers, who saved the monastery from destruction in the 1960-1980s. At the end of the article, the author raises the question about the possibility of new archaeological study and scientific-based restoration of the Dormition Cathedral of the monastery including the restoration of its historical five-headed shape, which is typical to such monuments of the 17th century. (shrink)

Vladimir Sergeevich Solov'ev was born on January 16, 1853, into the highly educated family of the outstanding Russian historian Sergei Mikhailovich Solov'ev. Solov'ev received his secondary education in the Fifth Moscow Gymnasium, and his higher education at Moscow University. At first Solov'ev studied in the Faculty of Physics and Mathematics. After three years and eight months there he left the university, but a few months later he stood his candidate's examination for the full university course in the Faculty of (...) History and Philology. At the same time as he was preparing his candidate's examination he audited lectures on theological and philosophical issues at the Moscow Spiritual Academy. (shrink)

This article highlights the participation of the Ukrainian scientist, Professor Vitaly Mikhailovich Grigorevsky, doctor of physical and mathematical sciences, and representative of the scientific school of Vladimir Platonovich Tsesevich, in the organization and development of international cooperative partnership in the field of satellite astronomy and photometric studies of artificial satellites of the Earth. The activity of the scientist in the coordination of scientific research of the countries of Eastern Europe in 1965–1973 under the SPIN program, carried out under the (...) auspices of the Astronomical Council of the USSR Academy of Sciences, is discussed. The article explores the main forms of Grigorevsky’s scientific cooperation with the world’s leading experts in the field of satellite astronomy—the British scientist Desmond King-Hele, the Czech astronomer František Link, Hungarian researchers Iván Almár and D. Toth, and others. Also, the achievements of the Latvian researchers Māris Ābele and Kasimirs Lapushka in the creation of photographic cameras of surveillance of satellites are analysed. (shrink)

We conducted two experiments to determine whether common folk think that so-called _tell-tale sign_ bald-faced lies are intended to deceive—since they have not been tested before. These lies involve tell-tale signs (e.g. blushing) that show that the speaker is lying. Our study was designed to avoid problems earlier studies raise (these studies focus on a kind of bald-faced lie in which supposedly everyone knows that what the speaker says is false). Our main hypothesis was that the participants will think that (...) the protagonists from our examples lied without intending to deceive, and the results of our surveys confirmed this hypothesis: most of our participants rated tell-tale sign lies as lies not intended to deceive. Therefore, our analysis suggests that common folk think that some lies are not intended to deceive. (shrink)

This paper examines the connection between lies, deception, and self-deception. Understanding this connection is important because the consensus is that you cannot deceive yourself by lying since you cannot make yourself believe as true a proposition you already believe is false – and, as a liar, you must assert a proposition you believe is false. My solution involves refining our analysis of lying: people can lie by asserting what they confidently believe is true. Thus, self-deceivers need not replace one belief (...) with another; rather, they may just increase existing credence in a proposition they already believe is true. (shrink)

A satisfactory analysis of human deception must rule out cases where it is a mistake or an accident that person B was misled by person A's behavior. Therefore, most scholars think that deceivers must intend to deceive. This article argues that there is a better solution: rather than appealing to the deceiver's intentions, we should appeal to the function of their behavior. After all, animals and plants engage in deception, and most of them are not capable of forming intentions. Accordingly, (...) certain human behavior is deceptive if and only if its function is to mislead. This solves our problem because if the function of A's behavior was to mislead, B's ending up misled was not an accident or a mere mistake even if A did not intend to deceive B. (shrink)

This paper argues that extant signalling-based analyses cannot explain a range of cases of biological (and psychological) deception, such as those in which the deceiver does not send a signal at all, but that Artiga and Paternotte’s (Philos Stud 175:579–600, 2018) functional and my (Krstić in The analysis of self-deception: rehabilitating the traditionalist account. PhD Dissertation, University of Auckland, 2018: §3; Krstić and Saville in Australas J Philos 97:830–835, 2019) manipulativist analyses can. Therefore, the latter views should be given preference. (...) And because we still do not have a satisfactory definition of manipulation, the functional analysis, according to which a state is deceptive iff its function is to mislead and it misleads, is currently our best theory of deception. This is not to argue that the signalling-based analyses have no value but only that they should not be used in general analyses of biological deception. We need to move on to some other interesting issues. (shrink)

In his article, Grossmann argues that, in the context of human cooperative caregiving, heightened fearfulness in children and human sensitivity to fear in others are adaptive traits. I offer and briefly defend a rival hypothesis: Heightened fearfulness among infants and young children is a maladaptive trait that did not get deselected in the process of evolution because human sensitivity to fear in others mitigates its disadvantageous effects to a sufficient extent.

We find an explicit basis for all admissible rules of the modal logic S4. Our basis consists of an infinite sequence of rules which have compact and simple, readable form and depend on increasing set of variables. This gives a basis for all quasi-identities valid in the free modal algebra ℱS4 of countable rank.

In this paper, I argue (1) that the contents of some delusions are believed with sufficient confidence; (2) that a delusional subject could have a conscious belief in the content of his delusion (p), and concurrently judge a contradictory content (not-p) – his delusion could be transparent, and (3) that the existence of even one such case reveals a problem with pretty much all existing accounts of lying, since it suggests that one can lie by asserting what one consciously and (...) confidently believes is true, and (4) sincerity, since it suggests that asserting a proposition you believe is true is neither sufficient nor necessary for sincerity. If I am right about (1) and (2), then (3) and (4) follow easily. Therefore, the paper is mainly devoted to an analysis of transparent delusion and defending (1) and (2). (shrink)

Deceptionism about lying is the view that all lies are intended to deceive. This view sits uneasily with some cases that seem to involve lies not intended to deceive. We call these lies bald-faced because the liar lies while believing that the hearer knows that they are lying. The most recent deceptionist argument put forward by Rudnicki and Odrowąż-Sypniewska (this journal) defends the view that all genuine bald-faced lies are intended to deceive some of their hearers. I argue that this (...) argument is interesting but problematic: its premises do not support the view that all bald-faced lies are intended to deceive but rather only that some people who bald-faced lie to institutions or large audiences intend to deceive someone. Also, genuine bald-faced lies addressed at institutions are intended to (non-deceptively) manipulate institutions rather than deceive anyone. (shrink)

The article attempts to raise a question and give an answer to it regarding the evaluation of the philosophical creativity of Hermann Cohen, the German-Jewish thinker of the late XIX - early XX century. Moreover, following the philosophical style of Cohen himself, the question posed and discussed in the article is not idle, but it contains a hypothesis that forms our answer in a certain way. It is important to identify the difficulties and intellectual determinants that prevent the formation of (...) a clear and unambiguous answer. At the same time these difficulties contain an initiating moment for opening a philosophical debate. The historical and philosophical reasons that make the very beginning of the discussion of the question more complex, are considered. The article, of course, cannot claim to be an exhaustive answer on such a fundamental topic, which is contained in the designated question. But the article itself, and the articles following it in the section devoted to the work of Herman Cohen, may be indicate that the time for this discussion has come. (shrink)

In this study, voluntary and involuntary visual attention focused on different interpretations of a bistable image, were investigated using magnetoencephalography. A Necker cube with sinusoidally modulated pixels' intensity in the front and rear faces with frequencies 6.67 Hz and 8.57 Hz, respectively, was presented to 12 healthy volunteers, who interpreted the cube as either left- or right-oriented. The tags of these frequencies and their second harmonics were identified in the average Fourier spectra of the MEG data recorded from the visual (...) cortex. In the first part of the experiment, the subjects were asked to voluntarily control their attention by interpreting the cube orientation as either being on the left or right. Accordingly, we observed the dominance of the corresponding spectral component, and voluntary attention performance was measured. In the second part of the experiment, the subjects were asked to focus their gaze on a red marker at the center of the cube image without putting forth effort in its interpretation. The alternation of the dominant spectral energies at the second harmonics of the stimulation frequencies was treated as changes in the cube orientation. Based on the results of the first experimental stage and using a wavelet analysis, we developed a method which allowed us to identify the currently perceived cube orientation. Finally, we characterized involuntary attention using the distribution of dominance times when focusing attention on one of the cube orientations, which was related to voluntary attention performance and brain noise. In particular, we confirmed our hypothesis that higher attention performance is associated with stronger brain noise. (shrink)

When we engage with fictions, we are, in effect, pretending to deal with reports of actual events. After all, numerous fictional works are explicitly designed to facilitate this kind of pretense. This was the prevailing understanding of fiction in both analytic philosophy and classical narratology for decades. However, there is a significant problem with this view: many fictional narratives routinely portray scenarios that could not possibly be the subject of anyone’s reporting. Currie’s 'mindless fictions' are one such example. This issue (...) can be referred to as the problem of unreportability. The standard solution to this challenge has been to argue that fictions are not pretend reports, but rather direct authorial stipulations to imagine specific scenarios. This paper contends, however, that such an explanation fails to provide a satisfactory account of fiction. By drawing on Walton’s notion of ‘silly questions’, it instead argues for a revised version of the report model-one that doesn’t necessarily depend on ubiquitous fictional reporters. (shrink)

The article deals with some items of Gödelian time travel problem well-known as an illustration of a specific kind of causality paradox. Its first part presents “the travel into the past” according to several recent physical hypotheses, which, from theoretical standpoint, seem to make such an idea possible. The familiar concept of backward causation is also discussed; we need to accept and develop it, if we wish to escape this type of time-travel paradoxes. The second part of the contribution is (...) devoted to philosophical interpretations of the precedence in order of cause and effect, and of the relation between temporal and causal order. The author claims, that if we wish to save coherent picture of nature, it is necessary to revise the concept of causality to make it compatible with the concept of backward causation. (shrink)

Tato stať se zabývá implicitním vztahem pojmu nutnosti a náhodnosti (bytí jsoucího) a pojmu zákona (bytí jsoucího) v Marxově filosofii spjaté (svázané) s explicitním vztahem pojmu nutnosti a náhodnosti (bytí lidsky jsoucího v ekonomicko-společenské bytné sféře) a pojmu zákona (bytí lidsky jsoucího v ekonomicko-společenské bytné sféře) v Marxově politické ekonomii a ukazuje její ontologicko-nomologické přednosti, poukazujíc však na její antropologicko-ontologické nedostatky, spjaté zvláště s jejím historicismem (s "bídou historicismu").

The travelling salesman problem (TSP) belongs to the class of NP-hard problems, in which an optimal solution to the problem cannot be obtained within a reasonable computational time for large-sized problems. To address TSP, we propose a hybrid algorithm, called GA-TCTIA-LBSA, in which a genetic algorithm (GA), tour construction and tour improvement algorithms (TCTIAs) and a list-based simulated annealing (LBSA) algorithm are used. The TCTIAs are introduced to generate a first population, and after that, a search is continued with the (...) GA. The problem of premature convergence of the GA to local optimum is tackled by a method called social disaster technique. Afterwards, the LBSA is applied to generate a new population based on one of two proposed operators called packing and judgement day. The proposed algorithm is implemented in the MATLAB environment, and its two variants, called GA-TCTIA-LBSA packing and GA-TCTIA-LBSA judgement day, are tested on symmetric and asymmetric instances from TSPLIB. The overall results demonstrate that the proposed GA-TCTIA-LBSAs offer promising results, particularly for small-sized instances. (shrink)

Im Unterschied zum christlichen Begriff der Gerechtigkeit als einer sittlichen Tugend, wie es Thomas von Aquin zusammenfasste, als einer Einstellung, kraft deren ein Mensch festen und steten Willens jedem sein Recht zukommen lässt, erkennt Nietzsche die Herkunft der Gerechtigkeit im Ausgleich oder Kompromiss zwischen ungefähr gleich Mächtigen sowie im Zwang der weniger Mächtigen zu einem Ausgleich. Zur Untermauerung dieser Einstellung, die sich auf der Behauptung gründet, dass das Leben seinem innersten Wesen nach eine Aneignung sei bzw. dass der Wille zur (...) Macht den Lebenswillen schlechthin ausmache, griff Nietzsche auf den von Thukydides geschilderten Dialog der Athener und Melier zurück. Der Autor kommt jedoch zu dem Schluss, dass Nietzsche nicht nur ein Denker der Macht war, sondern nach einem neuen Verständnis der Gerechtigkeit trachtete, das aus der Gesamtheit seines Denkens zu deuten sei. (shrink)

В трактате рассмотрены историко-философские аспекты современных любовных романов в стихах, написанных в русле эниологической поэзии. Для специалистов.

It is shown that, in some non-QCD theories, there are effects shared by QCD: (i) in SU(2) Yang–Mills theory containing a nonlinear spinor field, there is a mass gap; (ii) in SU(3) Proca–Higgs theory, there are flux tube solutions with a longitudinal electric field required for producing a force binding quarks; (iii) in non-Abelian Proca–Higgs theories, there exist flux tube solutions with a momentum directed along the tube axis and particlelike solutions with a nonvanishing total angular momentum created by crossed (...) color electric and magnetic fields; in QCD, such configurations may contribute to the proton spin. We discuss the conjecture that such non-QCD theories might be a consequence of approximate solution of an infinite set of Dyson–Schwinger equations describing the procedure of nonperturbative quantization. The phenomenon of dimensional transmutation for nonperturbative quantization and the analogy between nonperturbative quantization and turbulence modeling are also discussed. (shrink)

Prvi deo ovog rada, objavljen u prethodnom broju casopisa, bio je posvecen razmatranju religijskog porekla dvojnosti 'duha' i 'slova', a zatim i pitanju njenog znacenja u kontekstu filozofije ranog nemackog idealizma. Ovaj, drugi i zakljucni deo rada usredsredjuje se na eticke implikacije tog pitanja, posto je suprotstavljanje 'duha2 Kantovog sistema njegovom 'slovu', uz cesta pozivanja na novozavetno ispunjenje mojsijevskog zakona ljubavlju i verom predstavljalo jednu od osnovnih strategija kriticara Kantove teorije morala. Krajnja konsekvenca ovog pravca kritike Kanta lezi u ukidanju (...) autoriteta transcendentne moralne norme. Ovaj korak, kojim se istovremeno ponistava autoritet teksta kao takvog, a time i stav komentara kao literarnog zanra moze se uociti vec u Hegelovim mladalackim teoloskim spisima, u kojima se zastupa ukidanje transcendencije moralnog zakona njegovim inkorporiranjem u slobodnu subjektivnost koja egzistira u zajednici verujucih hriscana. (shrink)

Despite continuous efforts to reduce poverty on the global, national and communal levels the problem of closing the income gap remains serious. In this work, we analyze why the traditional infrastructure-based approach to development is becoming less effective. We have identified some features of the promising new approach, described in the collection of works "Self-Transformation of the Forgotten Four-Fifths" edited by Robert G. Dyck and Matjaz Mulej. The new approach could be applied in the information age when knowledge becomes a (...) key variable of development. (shrink)

The aim of this article is to compare two models of reality construction and their applicability to explain the various effects of the digitalization process. The evolution of the constructivist ideas about reality is reconstructed in the context of the dispute among realists and constructivists, which was one of the most significant events in the epistemology and philosophy of science of the 20th century. The author points out the differences between the intellectual and the social construction of reality, and carries (...) out a comparative analysis of the philosophical theories and concepts describing the aforementioned alternatives. The intellectual construction of reality, which often takes place in theoretical physics at different stages of its development, is also analyzed. Particular consideration is given to the philosophic-scientific contexts generated by the sociology of knowledge, the theory of speech acts, and the actor-network theory. The article also shows a distinction between the construction and the constitution of reality. The constitution of reality within various types of non-theoretical thinking, fixed using the means and methods of phenomenological philosophy of science, allows identifying and describing the main contexts through which the word reality acquires significance and is endowed with meaning in the present-day intellectual and social practices. Special attention is paid to the concepts of virtual reality and digital reality. The features of the intellectual construction of virtual reality are described. The difference between the intellectual and the social construction of digital reality is substantiated as between two alternative practices, which determine the meaning, and the prospects of digitalization. This distinction may be of particular interest to those who design digital platforms and implement digitalization in various areas of human life and society, especially in as education, legal procedure, management, economics, and business. Today, when partly spontaneous, partly controlled digitalization is taking place in these spheres, the results of this study make it possible not only to understand the logic of the changes taking place but also to apply forecasting and planning methods actively, i.e., constructing the digital reality. (shrink)

Trata-se de discutir a maneira com que as representações do corpo no cinema de David Cronenberg indicam uma dissociação importante entre gozo e prazer. Tal dissociação deve ser avaliada em sua dimensão propriamente política, abrindo com isso outra dimensão para aquilo que normalmente entendemos por “crítica do fetichismo”.

trata-se de discutir as relações entre a constituição da paranoia como categoria clínica e experiências estético-sociais de crise. Esta é uma maneira de se perguntar sobre as relações que categorias clínicas tecem com processos e valores advindos dos campos da política e da estética.

Based on some materials from the A.V. Florovsky's Foundation in the Archive of the Russian Academy of Sciences, the author of the article reconstructs a little-known page from the history of academic and philosophical life of the Russian migr, that is the history of the Philosophical Society at the Russian Free University in the 1930s-1940s, including during the Nazi occupation of Czechoslovakia. It is justified that the reconstruction of the history of Russian philosophical institutions can set a new research perspective (...) that allows us to consider the history of Russian philosophy as a process of formation and development of institutionalized forms of production, reproduction and translation of philosophical knowledge, which would allow to create a new historical and philosophical cross-section of Russian thought, complementing traditional approaches to the historiography of Russian philosophy. The article reveals new aspects of the scientific activity of N.O. Lossky and I.I. Lapshin, who played a key role in the work of the Philosophical Society. In addition, the analysis of archival materials made it possible to identify and reconstruct new facts from the creative biography of such thinkers of Russian emigration as S.L. Frank, E.V. Spektorsky, B.P. Vysheslavtsev, G.V. Florovsky. Russian Free University's Philosophical Society report for 1941 is given as an appendix to the article, as well as the reconstruction of the problems of the circle for the study of the Russian national idea. It is concluded that scientific and philosophical activity at the RSU was carried out through an extensive network of scientific societies, associations, circles and seminars, which allowed developing a wide variety of issues - aesthetics, the history of Russian and Western philosophy, philosophical problems of Russian literature and history, the Russian national idea. (shrink)

Рассказывая о традициях и содержании его религии, автор говорит о красоте и вдохновении, которыми искренняя вера в Бога награждает верующего. На страницах этой книги автор отводит особое место доказательству своего вывода о том, что религия и наука.

The implementation of the UN Sustainable Development Goals and the Lisbon Strategy sets the task of a comprehensive study of the citizens` well-being, determining the state and trends in the level and quality of life not only by traditional methods of social statistics, but also through comprehensive sociological research. This approach has significant advantages since it allows us to generalize the state of social development of a society based on the population`s opinions, to study the emerging social risks that concern (...) the population, to determine the differentiation of countries by indicators of well-being. The foundations of the new approach to the analysis of social processes were laid by the scientific achievements of the 60s of the last century. The dominant paradigm was the economic goals and parameters of statistically measured national income, household income, wages and their differentiation. The environmental risks that threaten the future of civilization were identified and analyzed in the 70s of the XX century. The production contradiction, which raised the question of measuring the quality of life in a new way, was articulated. The economic component was mixed and replaced with the welfare parameter. The sustainable development, including the indicators of well-being, the fight against poverty, and the environment were declared to be the goals of the society. The tasks of monitoring the solution of these problems are solved by sociological research, whose mathematical formalization can become a structural element of economic and mathematical modeling of social processes. (shrink)

The book presents two fundamental theories that characterize the cultural-historical perspective in cognitive semantics: the Four-Level Theory of Cognitive Development (FLTCD) and the Sociocultural Theory of Lexical Complexes (STLC) as well as their application to the analysis of specific material. In particular, the book analyzes the sociocultural history of the machine metaphor, specifically its use in the texts of René Descartes and Francis Bacon. The practical embodiment of STLC is demonstrated through the analysis of lexical complexes such as otkryvat' 'to (...) open,' kamen' 'stone,' and intelligencija 'intelligentsia.' In the final chapter of the monograph, FLTCD and STLC are used for the diachronic analysis of semantic change. The monograph will be of interest to a wide range of linguists, psychologists, cultural anthropologists, and philosophers who consider language as a sociocultural phenomenon. (shrink)

Chapters III–IV of De mixtione represent a new beginning of the treatise where the Stoics, the main target of Alexander’s critical assessment of preceding theories of blending, are presented in a more systematic manner than in the first chapters. Closer reading reveals that the context of the Stoic theory which Alexander is reporting is most probably the ontological query into the unity of the cosmos on its different levels in which the challenge is to distinguish blendings from other types of (...) unified objects. This can be done thanks to corresponding common notions, although these notions cannot stand for a firm and detailed grasp of the unified objects in question but are rather the means to make one acknowledge the existence of blending as a special kind of unity (between fusion and juxtaposition). The existence of this kind of unity is then supported by examples of analogical processes in which a result is achieved by the mutual interaction of two bodies upon each other or their mutual help. The conclusion should be that the Stoics’ effort to present a special kind of unity was part of their general account of the unity of the world which however did not include a claim about the blending of the first principles (insofar as cosmic pneuma is not such a principle). (shrink)

This article discusses the connection between the ideas of Fyodor M. Dostoevsky and Vladimir S. Solovyov on the need for cultural and moral transformation of those who would claim to participate in...

My dear Aleksandr!I have finally found some quiet time for a slow and attentive read of your article “The Beginning of the Black Notebooks.”1 I very much liked the article, especially for your trul...